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Activatable Molecular Probes for Cancer Imaging

[ Vol. 10 , Issue. 11 ]


Seulki Lee, Jin Xie and Xiaoyuan Chen   Pages 1135 - 1144 ( 10 )


The development of highly sensitive and specific molecular probes for cancer imaging still remains a daunting challenge. Recently, interdisciplinary research at the interface of imaging sciences and bionanoconjugation chemistry has generated novel activatable imaging probes that can provide high-resolution imaging with ultra-low background signals. Activatable imaging probes are designed to amplify output imaging signals in response to specific biomolecular recognition or environmental changes in real time. This review introduces and highlights the unique design strategies and applications of various activatable imaging probes in cancer imaging.


molecular probes, cancer imaging, imaging sciences, bionanoconjugation chemistry, activatable imaging probes, Molecular imaging, imaging techniques


Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), 31 Center Dr, Suite 1C14, Bethesda, MD 20892-2281.

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