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Peptide Ligands for the Melanin-Concentrating Hormone (MCH) Receptor 1

[ Vol. 7 , Issue. 15 ]

Author(s):

Maria A. Bednarek   Pages 1425 - 1432 ( 8 )

Abstract:


The melanin-concentrating hormone receptor 1 (MCH-1R) has been recognized as a receptor which mediates effects of the endogenous melanin-concentrating hormone (MCH) on appetite and body weight gain in rodents. In the last several years, a number of hMCH analogs have been designed which were potent and selective ligands for hMCH-1R. These peptidic agonists and antagonists have served as research tools in animal studies that showed a key role of the MCH-1R in the development of obesity and proved that MCH-1R antagonism can produce anti-obesity effects in rodents.

Keywords:

Melanin-concentrating hormone, melanin-concentrating hormone receptor, antagonist, obesity

Affiliation:

Merck Research Laboratories,R50G-140, 126 East Lincoln Avenue, Rahway, NJ 07065, USA.



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