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FtsZ: A Novel Target for Tuberculosis Drug Discovery

[ Vol. 7 , Issue. 5 ]

Author(s):

Qing Huang, Peter J. Tonge, Richard A. Slayden, Teruo Kirikae and Iwao Ojima   Pages 527 - 543 ( 17 )

Abstract:


The emergence of multi-drug resistant Mycobacterium tuberculosis (Mtb) strains has made many of the currently available anti-TB drugs ineffective. Accordingly there is a pressing need to identify new drug targets. FtsZ, a bacterial tubulin homologue, is an essential cell division protein that polymerizes in a GTP-dependent manner, forming a highly dynamic cytokinetic ring, designated as the Z ring, at the septum site. Following recruitment of other cell division proteins, the Z ring contracts, resulting in closure of the septum and then formation of two daughter cells. Since inactivation of FtsZ or alteration of FtsZ assembly results in the inhibition of Z ring and septum formation, FtsZ is a very promising target for new antimicrobial drug development. This review describes the function and dynamic behaviors of FtsZ, its homology to tubulin, and recent development of FtsZ inhibitors as potential anti-TB agents.

Keywords:

FtsZ, tubulin, GTPase, homology, GTP hydrolysis, polymerization, dynamics, inhibitor

Affiliation:

Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794-3400, USA.



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