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Article Details


Fluorinated Natural Products with Clinical Significance

[ Vol. 6 , Issue. 14 ]

Author(s):

Craig J. Thomas   Pages 1529 - 1543 ( 15 )

Abstract:


The modification of natural products in an effort to alter their biochemical capacity is a common technique utilized by synthetic and medicinal chemists. Fluorine substitution imparts unique and advantageous physiochemical properties that can be shrewdly employed to constructively alter pharmacological agents. The adornment of natural products with fluorine has proven beneficial in several examples. This overview discusses several of the most relevant fluorinated natural products under current examination.

Keywords:

Natural products, fluorine, camptothecin, artemisinin, Vinca alkaloids, taxanes, epothilones

Affiliation:

NIDDK, NIH, 9000 Rockville Pike, Bldg 8, Room 117, Bethesda, MD 20892.



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