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Fluorinated Nucleosides as Antiviral and Antitumor Agents

[ Vol. 6 , Issue. 14 ]

Author(s):

Wei-Dong Meng and Feng-Ling Qing   Pages 1499 - 1528 ( 30 )

Abstract:


The synthesis of nucleosides and analogues with fluoride modifications on the surgar moiety are reviewed, and their biological activities as potential antiviral and anti-tumor agents are also discussed.

Keywords:

diethylaminosulfur trifluoride (DAST), purine analogues, Carbocyclic nucleosides, L-pyranosyl nucleosides, cyclopropane, DNA and RNA viruses

Affiliation:

Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.



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