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A Review on Natural Sources Derived Protein Nanoparticles as Anticancer Agents

Author(s):

Tanima Bhattacharya, Samka Peregrine Maishu, Rokeya Akter, Md. Habibur Rahman*, Muhammad Furqan Akhtar, Ammara Saleem, May Bin-Jumah, Mohamed Kamel, Mervat A. Abdel-Latif and Mohamed M. Abdel-Daim*  

Abstract:


Cancer notably carcinoma represents a prominent health challenge worldwide. A variety of chemotherapeutic agents are being used to deal with a variety of carcinomas. However, these delivering agents not only enter the targeted site but also affect normal tissues yielding poor therapeutic outcomes. Chemotherapeutic-associated problems are been attributed to drug non-specificity resulting from poor drug delivery systems. These problems are now been solved using nanomedicine which entails using nanoparticles as drug delivery systems or nanocarriers. This nanoparticle-based drug delivery system enhances clinical outcomes by enabling targeted delivery, improving drug internalization, enhanced permeability, easy biodistribution, prolonged circulation and enhanced permeability rate thereby improving therapeutic effectiveness of several anticancer agents. Natural protein-based nanoparticles (PNPs) such as ferritin, lipoprotein, and lectins from natural sources have gained extensive importance at scientific community level as nanovehicle for effective drug delivery and photo acoustic labeling replacing several synthetic nanocarriers that have shown limited therapeutic outcomes. The bioavailability of PNP, chance of genetic engineering techniques to modify their biological properties made them one of the important raw material sources for drug delivery research. This current review highlighted different chemotherapeutic agents used in the treatment of some carcinomas. It also focused on the wide variety of natural protein sources derived nanoparticles (NPs) as anticancer delivery of agents for cancer therapy.

Keywords:

Drug delivery system, nanomedicine, carcinoma, nanoparticles, mushroom.

Affiliation:

Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, Department of Biochemistry, University of Bamenda, North Western, Department of Pharmacy, Jagannath University, Sadarghat, Dhaka-1100, Department of Pharmacy, Southeast University, Banani, Dhaka-1213, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Department of Biology, College of Science, Princess Nourahbint Abdurrahman University, Riyadh 11474, Department of Medicine and Infectious Diseases, Faculty of Veterinary Medicine, 12211, Giza, Cairo University, Department of Nutrition and Veterinary Clinical Nutrition, Faculty of Veterinary Medicine, iDamanhour University, Damanhour 22511, Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451



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