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Potential Therapeutic Relevance of CRISPR/Cas9 Guided Epigenetic Regulations for Neuropsychiatric Disorders

Author(s):

Desh Deepak Singh*, Ravi Verma, Piyush Parimoo, Ashish Sahu, Vikram Kumar, Era Upadhyay and Dharmendra Kumar Yadav   Pages 1 - 17 ( 17 )

Abstract:


Brain function activity is regulated by several mechanisms of genetic and epigenetic factors such as histone modelling, DNA methylation, and non-coding RNA. Alteration in these regulatory mechanisms affect normal development of neurons that causes Neuropsychiatric Disorders (ND). However, it is required to analyse the functional significance of neuropsychiatric disorders associated to molecular mechanism to therapeutic advances in early diagnosis and treatment of the patients. The CRISPR/Cas 9 (Clustered Regularly Interspaced Short Palindromic Repeats) genome editing tools have revolutionized multiple genome and epigenome manipulation targets same time. This review discussed the possibilities about using CRISPR/Cas 9 tools during molecular mechanism in the ND, to obtain therapeutic approach of this amazing technique to overcome ND that generates because of genetics and epigenetic abnormalities.

Keywords:

Neuropsychiatric Disorders, Epigenetic regulations, Transcription factor, CRISPR/Cas9, gene editing, neuronal development, Therapeutic applications

Affiliation:

Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang 37673, Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, Amity Institute of Biotechnology, Amity University Rajasthan, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang 37673



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