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Potential Therapeutic Relevance of CRISPR/Cas9 Guided Epigenetic Regulations for Neuropsychiatric Disorders

[ Vol. 21 , Issue. 10 ]

Author(s):

Desh D. Singh*, Ravi Verma, Piyush Parimoo, Ashish Sahu, Vikram Kumar, Era Upadhyay and Dharmendra K. Yadav   Pages 878 - 894 ( 17 )

Abstract:


Brain function activity is regulated by several mechanisms of genetic and epigenetic factors such as histone modelling, DNA methylation, and non-coding RNA. Alterations in these regulatory mechanisms affect the normal development of neurons that causes Neuropsychiatric Disorders (ND). However, it is required to analyse the functional significance of neuropsychiatric disorders associated with a molecular mechanism to bring about therapeutic advances in early diagnosis and treatment of the patients. The CRISPR/Cas 9 (Clustered Regularly Interspaced Short Palindromic Repeats) genome editing tools have revolutionized multiple genome and epigenome manipulation targets the same time. This review discussed the possibilities of using CRISPR/Cas 9 tools during molecular mechanism in the ND as a therapeutic approach to overcome ND that is caused due to genetic and epigenetic abnormalities.

Keywords:

Neuropsychiatric Disorders, Epigenetic regulations, Transcription factor, CRISPR/Cas9, Gene editing, Neuronal development, Therapeutic applications.

Affiliation:

Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang37673, Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur, College of Pharmacy, Gachon University of Medicine and Science, Hambakmoeiro 191, Yeonsu-gu, Incheon City

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