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Therapeutic Potential of microRNA Against Th2-associated Immune Disorders

[ Vol. 21 , Issue. 8 ]

Author(s):

Sunil Kumar, Muhammad Umer Ashraf, Anil Kumar and Yong-Soo Bae*   Pages 753 - 766 ( 14 )

Abstract:


MicroRNAs (miRNAs) are short ~18-22 nucleotide, single-stranded, non-coding RNA molecules playing a crucial role in regulating diverse biological processes and are frequently dysregulated during disease pathogenesis. Thus, targeting miRNA could be a potential candidate for therapeutic invention. This systemic review aims to summarize our current understanding regarding the role of miRNAs associated with Th2-mediated immune disorders and strategies for therapeutic drug development and current clinical trials.

Keywords:

microRNA therapeutics, Th2-disorder, Dendritic cells, Asthma, Atopic dermatitis, Rhinitis.

Affiliation:

Department of Biological Sciences, Science Research Center (SRC) for Immune Research on Non-lymphoid Organ (CIRNO), Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, Department of Biological Sciences, Science Research Center (SRC) for Immune Research on Non-lymphoid Organ (CIRNO), Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419, Amity Institute of Biotechnology, Amity University Haryana, Amity Education Valley, Gurugram-122413, Department of Biological Sciences, Science Research Center (SRC) for Immune Research on Non-lymphoid Organ (CIRNO), Sungkyunkwan University, Jangan-gu, Suwon, Gyeonggi-do 16419

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