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Current Challenges and Implications of Proteogenomic Approaches in Prostate Cancer

[ Vol. 20 , Issue. 22 ]

Author(s):

Nidhi Shukla, Narmadhaa Siva, Babita Malik and Prashanth Suravajhala*   Pages 1968 - 1980 ( 13 )

Abstract:


In the recent past, next-generation sequencing (NGS) approaches have heralded the omics era. With NGS data burgeoning, there arose a need to disseminate the omic data better. Proteogenomics has been vividly used for characterising the functions of candidate genes and is applied in ascertaining various diseased phenotypes, including cancers. However, not much is known about the role and application of proteogenomics, especially Prostate Cancer (PCa). In this review, we outline the need for proteogenomic approaches, their applications and their role in PCa.

Keywords:

Prostate Cancer, Next-Generation sequencing, Genomics, Proteomics, Proteogenomics, Transcriptomics, Phosphoproteomics.

Affiliation:

Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Statue Circle, Jaipur 302001, RJ, Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Statue Circle, Jaipur 302001, RJ, Department of Chemistry, School of Basic Sciences, Manipal University Jaipur, Jaipur, Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Statue Circle, Jaipur 302001, RJ

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