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Exploring the Potential of Neuroproteomics in Alzheimer's Disease

[ Vol. 20 , Issue. 25 ]

Author(s):

Md. Sahab Uddin*, Md. Tanvir Kabir, Md. Jakaria, Eduardo Sobarzo-Sánchez, George E. Barreto, Asma Perveen, Abdul Hafeez, May N. Bin-Jumah, Mohamed M. Abdel-Daim and Ghulam M. Ashraf*   Pages 2263 - 2278 ( 16 )

Abstract:


Alzheimer's disease (AD) is progressive brain amyloidosis that damages brain regions associated with memory, thinking, behavioral and social skills. Neuropathologically, AD is characterized by intraneuronal hyperphosphorylated tau inclusions as neurofibrillary tangles (NFTs), and buildup of extracellular amyloid-beta (Aβ) peptide as senile plaques. Several biomarker tests capturing these pathologies have been developed. However, for the full clinical expression of the neurodegenerative events of AD, there exist other central molecular pathways. In terms of understanding the unidentified underlying processes for the progression and development of AD, a complete comprehension of the structure and composition of atypical aggregation of proteins is essential. Presently, to aid the prognosis, diagnosis, detection, and development of drug targets in AD, neuroproteomics is elected as one of the leading essential tools for the efficient exploratory discovery of prospective biomarker candidates estimated to play a crucial role. Therefore, the aim of this review is to present the role of neuroproteomics to analyze the complexity of AD.

Keywords:

Neuroproteomics, Alzheimer's Disease, Amyloid precursor protein, Amyloid-beta, Tau, Microglia, Biomarkers.

Affiliation:

Department of Pharmacy, Southeast University, Dhaka, Department of Pharmacy, Brac University, Dhaka, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Instituto de Investigacion e Innovacion en Salud, Facultad de Ciencias de la Salud, Universidad Central de Chile, Department of Biological Sciences, University of Limerick, Limerick, Glocal School of Life Sciences, Glocal University, Saharanpur, Glocal School of Pharmacy, Glocal University, Saharanpur, Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11474, Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, King Fahd Medical Research Center, King Abdulaziz University, Jeddah

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