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Emerging Proof of Protein Misfolding and Interactions in Multifactorial Alzheimer's Disease

[ Vol. 20 , Issue. 26 ]

Author(s):

Md. Sahab Uddin*, Abdullah Al Mamun, Md. Ataur Rahman, Tapan Behl, Asma Perveen, Abdul Hafeez, May N. Bin-Jumah, Mohamed M. Abdel-Daim and Ghulam Md Ashraf*   Pages 2380 - 2390 ( 11 )

Abstract:


Objective: Alzheimer's disease (AD) is a devastating neurodegenerative disorder, characterized by the extracellular accumulations of amyloid beta (Aβ) as senile plaques and intracellular aggregations of tau in the form of neurofibrillary tangles (NFTs) in specific brain regions. In this review, we focus on the interaction of Aβ and tau with cytosolic proteins and several cell organelles as well as associated neurotoxicity in AD.

Summary: Misfolded proteins present in cells accompanied by correctly folded, intermediately folded, as well as unfolded species. Misfolded proteins can be degraded or refolded properly with the aid of chaperone proteins, which are playing a pivotal role in protein folding, trafficking as well as intermediate stabilization in healthy cells. The continuous aggregation of misfolded proteins in the absence of their proper clearance could result in amyloid disease including AD. The neuropathological changes of AD brain include the atypical cellular accumulation of misfolded proteins as well as the loss of neurons and synapses in the cerebral cortex and certain subcortical regions. The mechanism of neurodegeneration in AD that leads to severe neuronal cell death and memory dysfunctions is not completely understood until now.

Conclusion: Examining the impact, as well as the consequences of protein misfolding, could help to uncover the molecular etiologies behind the complicated AD pathogenesis.

Keywords:

Aβ, Tau, Protein misfolding, Protein interaction, Neurotoxicity, Alzheimer's disease.

Affiliation:

Department of Pharmacy, Southeast University, Dhaka, Department of Pharmacy, Southeast University, Dhaka, Center for Neuroscience, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Chitkara College of Pharmacy, Chitkara University, Punjab, Glocal School of Life Sciences, Glocal University, Saharanpur, Glocal School of Pharmacy, Glocal University, Saharanpur, Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11474, Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, King Fahd Medical Research Center, King Abdulaziz University, Jeddah

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