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Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors

[ Vol. 20 , Issue. 10 ]

Author(s):

Dima A. Sabbah*, Rima Hajjo and Kamal Sweidan   Pages 815 - 834 ( 20 )

Abstract:


The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation, division, survival, and cancer development. In this review, the EGFR structure and its mutations, signaling pathway, ligand binding and EGFR dimerization, EGF/EGFR interaction, and the progress in the development of EGFR inhibitors have been explored.

Keywords:

EGFR, HER-1, ERBB-1, Tyrosine kinase, EGF, TGF-α, mAbs, Inhibitors, cancer.

Affiliation:

Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, P.O. Box 130, Amman 11733, Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, P.O. Box 130, Amman 11733, Department of Chemistry, The University of Jordan, Amman 11942

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