Mukesh C. Joshi* and Timothy J. Egan Pages 617 - 697 ( 81 )
The side-chains of quinoline antimalarial agents are the major concern of focus to build novel and efficaciaous bioactive and clinical antimalarials. Bioative antimalarial analogs may play a critical role in pH trapping in the food vacuole of RBC’s with the help of fragmented amino acid, thus lead to β-hematin inhibition. Here, the authors tried to summarize a useful, comprehensive compilation of side-chain modified ACQs along with their synthesis, biophysical and therapeutic applications etc. of potent antiplasmodial agents and therefore, opening the door towards the potential clinical status.
Chloroquine, P. falciparum, Antiplasmodial activity, β-HI activity, Cytotoxicity, Quinoline.
Department of Chemistry, Motilal Nehru College, Benito Juarez Marg, South Campus, University of Delhi, New Delhi- 110021, Department of Chemistry, University of Cape Town, Rondebosch 7701