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A Paradigm Shift in the Development of Anti-Candida Drugs

[ Vol. 19 , Issue. 28 ]

Author(s):

D.V. Gowda*, M. Afrasim, S.I. Meenakshi, M. Manohar, S. Hemalatha, H. Siddaramaiah, P. Sathishbabu, S.M. Danish Rizvi, T. Hussain and M.A. Kamal   Pages 2610 - 2628 ( 19 )

Abstract:


Background: The considerable increase in the incidence of Candida infection in recent times has prompted the use of numerous antifungal agents, which has resulted in the development of resistance towards various antifungal agents. With rising Candida infections, the need for design and development of novel antifungal agents is in great demand. However, new therapeutic approaches are very essential in preventing the mortality rate and improving the patient outcome in those suffering from Candida infections.

Objective: The present review objective is to describe the burden, types of Candidiasis, mechanism of action of antifungal agents and its resistance and the current novel approaches used to combat candidiasis.

Methods: We have collected and analyzed 135 different peer-reviewed literature studies pertinent to candidiasis. In this review, we have compiled the major findings from these studies.

Results and Conclusion: The review describes the concerns related to candidiasis, its current treatment strategy, resistance mechanisms and imminent ways to tackle the problem. The review explored that natural plant extracts and essential oils could act as sources of newer therapeutic agents, however, the focus was on novel strategies, such as combinational therapy, new antibodies, utilization of photodynamic therapy and adaptive transfer primed immune cells with emphasis on the development of effective vaccination.

Keywords:

Candidiasis, Antifungal agents, Natural plant extracts, Novel drug therapy, Vaccination, VVC.

Affiliation:

Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru- 570015, Department of Pharmaceutics, Hail University, Hail, Department of Prosthodontics and Crown & Bridge, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysuru-570015, Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru- 570015, Department of Anaesthesia, JSS Medical College & Hospital, JSS Academy of Higher Education and Research, Mysuru - 570004, Department of Polymer Science and Technology, Sri Jayachamarajendra College of Engineering, JSS Science and Technology University, Mysuru - 570006, Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru- 570015, Department of Pharmaceutics, Hail University, Hail, Department of Pharmacology and Toxicology, University of Hail, Hail, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589

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