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Recent Development of Coumarin Derivatives as Potential Antiplasmodial and Antimalarial Agents

[ Vol. 18 , Issue. 2 ]


Xin-Liang Hu, Chuan Gao, Zhi Xu, Ming-Liang Liu, Lian-Shun Feng and Guang-De Zhang*   Pages 114 - 123 ( 10 )


Malaria still remains one of the leading deadliest diseases throughout the world, leading to around 1 million deaths annually. The emergence and spread of growing resistance to the firstline antimalarials are an alarming the serious problem in malaria control, demanding the need for new drugs more potent than earlier with improved Absorption, Distribution, Metabolism, and Excretion (ADME) profiles. Coumarins, which exhibited various biological properties, also displayed potential in vitro antiplasmodial and in vivo antimalarial activities. Moreover, many of coumarin derivatives have already been used in clinical practice for the treatment of several diseases. Therefore, coumarin derivatives play a pivotal role in medicinal chemistry, also making them promising candidates for the treatment of malaria. This review aims to summarize the recent advances made towards the development of coumarin-containing derivatives as antiplasmodial and antimalarial agents and their structure-activity relationship is also discussed.


Malaria, plasmodium, coumarin, hybrid compounds, structure-activity relationship, antiplasmodial.


School of Chemistry and Materials Science, Hubei Engineering University, Xiaogan, Hubei, WuXi AppTec (Wuhan), Hubei, Key Laboratory of Hubei Province for Coal Conversion and New Carbon Materials, Wuhan University of Science and Technology, Hubei, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, WuXi AppTec (Wuhan), Hubei, School of Automobile and Traffic Engineering, Wuhan University of Science and Technology, Wuhan

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