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C. elegans as Model for Drug Discovery

[ Vol. 17 , Issue. 18 ]

Author(s):

Maria Carretero, Gregory M. Solis and Michael Petrascheck*   Pages 2067 - 2076 ( 10 )

Abstract:


Small molecule screens using C. elegans as a model are becoming increasingly popular as the number of high-throughput methodologies has steadily increased over the years. Here we focus on the biology that underlies this increased popularity and outline the reasons that make C. elegans an attractive model for drug discovery. We discuss successful C. elegans based drug discovery projects in the literature and future challenges ahead.

Keywords:

C. elegans, Cancer biology, HTS, Nematodes, Vertebrate vascular endothelial growth factors, Drug discovery.

Affiliation:

Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA, Department of Chemical Physiology, Department of Molecular and Experimental Medicine, Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA

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