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Exploiting Quorum Sensing Inhibition for the Control of Pseudomonas aeruginosa and Acinetobacter baumannii Biofilms

[ Vol. 17 , Issue. 17 ]

Author(s):

Israel Castillo-Juarez, Luis Esau Lopez-Jacome, Gloria Soberon-Chavez, Maria Tomas, Jintae Lee, Paulina Castaneda-Tamez, Ivan Angelo Hernandez-Barragan, Martha Yumiko Cruz-Muniz, Toshinari Maeda, Thomas K. Wood and Rodolfo Garcia-Contreras*   Pages 1915 - 1927 ( 13 )

Abstract:


Pseudomonas aeruginosa and Acinetobacter baumannii are two of the main bacteria responsible for nosocomial infections; both organisms are resistant to several classes of antibiotics making their infections very difficult to treat. Moreover, they possess a remarkable ability to form biofilms, which further enhances their antimicrobial resistance. Both organisms coordinate their formation of biofilms and their expression of virulence factors through quorum sensing, a system that regulates gene expression at high cell densities and that plays a key role in the establishment of bacterial infections. Hence, interfering with these quorum-sensing systems has been proposed as an alternative to traditional antibiotics for the eradication of bacterial infections. In this review, we describe the quorum sensing systems of both organisms, the way they coordinate the formation of biofilms, the recent advances in biofilm disruption by quorum sensing interference, and the advantages and limitations of the implementation of these novel therapeutic options in the clinic.

Keywords:

Quorum quenching, Homoserine lactone, In vivo biofilm models, Stress response, Resistance.

Affiliation:

Colegio de Postgraduados, Campus Montecillo, Texcoco, Department of Microbiology and Parasitology, Faculty of Medicine, UNAM, Mexico City, Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Department of Microbiology, Instituto de Investigacion Biomedica de A Coruna (INIBIC), Complexo Hospitalario Universitario de A Coruna (CHUAC), Sergas, Universidade da Coruna, A Coruna, School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Colegio de Postgraduados, Campus Montecillo, Texcoco, Colegio de Postgraduados, Campus Montecillo, Texcoco, Colegio de Postgraduados, Campus Montecillo, Texcoco, Department of Biological Functions and Engineering, Kyushu Institute of Technology, Kitakyushu, Departments of Chemical Engineering and Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, Department of Microbiology and Parasitology, Faculty of Medicine, UNAM, P.O. Box: 04890, Mexico City

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