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Structure and Function of the Non-Structural Protein of Dengue Virus and its Applications in Antiviral Therapy

[ Vol. 17 , Issue. 3 ]

Author(s):

Qian Xie, Bao Zhang, JianHai Yu, Qinghua Wu, Fangji Yang, Hong Cao and Wei Zhao   Pages 371 - 380 ( 10 )

Abstract:


Dengue fever, a type of global and tropical infectious disease, and its prevention has become a challenging issue worldwide. Antibody-dependent enhancement effects and the virus pathogenic mechanism have not yet been fully elucidated, hindering the development of dengue fever prevention and suitable drug treatment. There is currently no specific prevention and therapy in clinical trials, however, in recent years, studies have focused on the pathogenesis and treatment of dengue. Research focusing on dengue virus nonstructural protein in special drugs for the prevention and control of dengue fever is a new progress leading to improved understanding regarding the prevention and control of dengue fever and suitable drugs for the treatment. The main challenges regarding the structure of dengue virus nonstructural protein and the drugs for antiviral therapy are summarized in this paper.

Keywords:

Dengue virus, Non-structural protein, Structure, Function, Antiviral therapy.

Affiliation:

Lab of Biosafety Level 3, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515,China.

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