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A Medical Approach to the Monoamine Oxidase Inhibition by Using 7Hbenzo[ e]perimidin-7-one Derivatives

[ Vol. 17 , Issue. 4 ]

Author(s):

Mitchell Bacho, Eduardo Coelho-Cerqueira, Cristian Follmer, Seyed Mohammad Nabavi, Luca Rastrelli, Eugenio Uriarte and Eduardo Sobarzo-Sanchez   Pages 489 - 497 ( 9 )

Abstract:


Background: A series of perimidinone derivatives (7H-benzo[e]perimidin-7-one) were synthesized and assessed by means of in vitro assays as human MAO inhibitors. These compounds inhibited reversibly the enzymes with inhibitory constants in the range of 2 to 20 μM. In addition, the selectivity of inhibition of the MAO isoforms seems to be significantly dependent of the presence either of heteroatom or electron donating and withdrawing groups on the perimidinone framework, which was verified by using molecular docking simulation with the crystallized MAO receptors. Most of these inhibitors were highly selective: 9 and 11 inhibited selectively the MAO-B isoform while 12 had 10-fold selectivity for MAO-A isoform. Moreover, the compound 12 was both the most selective and potent MAO-A inhibitor among perimidinones.

Result: These results have important implications for the drug design of molecules targeting depression and movement-related disorders.

Keywords:

Monoamine oxidase (MAO), 7H-benzo[e]perimidin-7-one, Perimidinones, MAO-A, Anti-Parkinson.

Affiliation:

Laboratory of Pharmaceutical Chemistry, Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain.

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