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Heterocyclic Compounds: Effective α-Amylase and α-Glucosidase Inhibitors

[ Vol. 17 , Issue. 4 ]

Author(s):

Mina Saeedi, Abbas Hadjiakhondi, Seyed Mohammad Nabavi and Azadeh Manayi   Pages 428 - 440 ( 13 )

Abstract:


Diabetes Mellitus (DM) is a metabolic disease characterized by high blood sugar levels. Recently, it has emerged as an important and global health problem with long-term complications and high economic burden. α-Amylase (α-Amy) and α-glucosidase (α-Gls) are two enzymes which are involved in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose level. Hence, inhibition of α-amylase and α-glucosidase plays key role in the treatment of type 2 diabetes. Heterocyclic compounds -both synthetic and naturally occurring derivatives- possess efficient biological properties. At this juncture, they have demonstrated potent inhibitory activity against α-Amy and α-Gls and were found to be versatile tools for the development of novel anti-diabetic agents.

Keywords:

α-Amylase, α-Glucosidase, Diabetes, Heterocycles, Synthesis, Natural Products.

Affiliation:

Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

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