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Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization

[ Vol. 17 , Issue. 2 ]


  Pages 120 - 137 ( 18 )


Indole is a potential lead for drug design which has been found in numerous pharmaceutically important compounds due to its medicinal properties, such as anti-tumor, anti-bacterial, anti-virus and anti-inflammatory. In the last decade, interfering with microtubule polymerization, a potential orientation to cause cell cycle arrest and apoptosis has become a promising method for cancer therapy. Thus, indole-based agents capable to modulate the microtubule assembly have gained considerable interest among scientists. This review describes the synthesis, bioactivities and SARs of indole-based agents targeting tubulin polymerization during the past decade.


Indole, Microtubule Polymerization, Anti-tumor, Apoptosis.

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