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Bispidine as a Privileged Scaffold

[ Vol. 16 , Issue. 11 ]


Isabelle Tomassoli and Daniela Gündisch   Pages 1314 - 1342 ( 29 )


Thediazabicyclic molecule bispidine named by the chemist Carl Mannich in 1930, is a naturally occurring scaffold with interesting features. Bispidine can form different conformers, has high basicity, can attack dichloromethane, has metal ion coordination properties and interacts with nicotinic acetylcholine receptors. In this review we will discuss important properties, synthetic pathways and biological activities of bispidine and some derivatives. Bispidine can function as a scaffold for compounds with very diverse biological activities, e.g. interacting with ion channels, G-protein coupled receptors, and enzymes, and is even used for the development of new in vivo radiotracers.


Bispidine, cytisine, 3, 7-diazabicyclo[3.3.1]nonane, radiotracer, receptor, scaffold, sparteine.Bispidine, cytisine, 3, 7-diazabicyclo[3.3.1]nonane, radiotracer, receptor, scaffold, sparteine.


Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai’i at Hilo, 34 Rainbow Drive, Hilo, HI 96720, U.S.A

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