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Recent Progress on Bioinformatics, Functional Genomics, and Metabolomics Research of Cytochrome P450 and its Impact on Drug Discovery

[ Vol. 12 , Issue. 12 ]

Author(s):

Tao Zhang, Mingzhu Zhao, Yushu Pang, Wen Zhang, Limin Angela Liu and Dong-Qing Wei   Pages 1346 - 1355 ( 10 )

Abstract:


The cytochrome P450 superfamily is responsible primarily for human drug metabolism, which is of critical importance for the drug discovery and development. Rapid advancement of bioinformatics, functional genomics and metabolomics has been made over the last decade. These disciplines are essential in target identification, lead discovery and optimization. In this review, we summarize the recent progress on cytochrome P450 and its role on drug metabolism in the context of bioinformatics, functional genomics and metabolomics. Data are integrated into various databases and webbased platforms on cytochrome P450. These research tools and resources are playing an increasingly important role in drug discovery, and are helping in achieving the ultimate goal of personalized medicine, that is, to prescribe personalized drugs according to each person’s genetic makeup, metabolic level, and drug disposition.

Keywords:

Bioinformatics, cytochrome P450, drug development, functional genomics, metabolomics, Metabolomics Research, drug discovery, lead discovery, genetic makeup, metabolic level, drug disposition

Affiliation:

Fred Hutchinson Cancer Research Center, Seattle WA, USA 98109.



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