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Glutamatergic Neurotransmission As Molecular Target of New Anticonvulsants

[ Vol. 12 , Issue. 9 ]

Author(s):

Rosaria Gitto, Laura De Luca, Sara De Grazia and Alba Chimirri   Pages 971 - 993 ( 23 )

Abstract:


Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) controlling physiological processes as learning and memory. However, the overactivation of glutamatergic neurotransmission is often related to various CNS chronic and acute diseases (epilepsy, ischaemia, Parkinson, etc.). This review will focus on the chemical structures, mechanism of action and main structure-activity relationships of anticonvulsant agents acting through glutamate neurotransmission.

Keywords:

AMPA, anticonvulsants, epilepsy, glutamate, glutamate transporters, iGluR, mGluR

Affiliation:

Dipartimento Farmaco- Chimico, Universita di Messina, Viale Annunziata, 98168 Messina, Italy.



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