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Improvement of Tumor Localization of Photosensitizers for Photodynamic Therapy and Its Application for Tumor Diagnosis

[ Vol. 12 , Issue. 3 ]

Author(s):

Shun-Ichiro Ogura, Yuichiro Hagiya, Kenji Tabata, Toshiaki Kamachi and Ichiro Okura   Pages 176 - 184 ( 9 )

Abstract:


Photodynamic therapy (PDT) and photodynamic diagnosis of cancer are widely used in clinical fields. These are performed using photosensitizers. Many metalloporphyrin-related compounds have been developed as photosensitizers for use in PDT, and these tumor localization ability have been improved in recent research. Moreover, the precursor of porphyrin 5-aminolevulinic acid is used in fluorescence diagnosis using its tumor localization ability. In this review, these applications of photosensitizers in cancer therapy and diagnosis are summarized.

Keywords:

Photodynamic therapy, phthalocyanine, aminolevulinic acid, immunoconjugate, photodynamic diagnosis, tumor marker, porphyrin 5-aminolevulinic acid, ophthalmic tumors, fluorescence diagnosis, target tissues, photosensitizer, hematoporphyrin derivative, tumor tissue occurs, hemoglobin, photodynamic treatment

Affiliation:

4259-B102, Nagatsuta-cho,Midori-ku, Yokohama 226-8501, Japan.



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