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Thematic Analysis™ : A Chemogenomic Approach to GPCR Drug Discovery

[ Vol. 11 , Issue. 15 ]

Author(s):

Roger Crossley, Jacqueline Anne Macritchie and Martin John Slater   Pages 1925 - 1943 ( 19 )

Abstract:


Thematic Analysis™ is a chemogenomic tool which has been developed and used to aid the process of GPCR drug discovery. This review covers the scientific rationale behind the development of this tool and provides examples of the successful application of the chemogenomic method in both hit finding and hit to lead stages of the drug discovery process.

Keywords:

Chemogenomics, drug discovery, focused libraries, GPCR, library design, Thematic Analysis™, chemogenomic tool, High Throughput Screening (HTS), virtual screening, structure activity relationships (SAR), selection of compounds from a diverse compound set, rational design of a focused library, chemical scaffold

Affiliation:

Cresset BioMolecular Discovery Ltd, BioPark Hertfordshire, Broadwater Road, Welwyn Garden City, Herts, AL7 3AX, UK.



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