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Natural Products as a Source of Protein Kinase Activators and Inhibitors

[ Vol. 11 , Issue. 11 ]


Andrew Marston   Pages 1333 - 1339 ( 7 )


Many of the protein kinase activators and inhibitors presently under investigation are natural products or are derivatives of natural products. Since over 500 kinases are encoded by the human genome, the task is to discover modulatory compounds which have high specificity for a single enzyme. Many different low molecular weight compounds have been studied for activity. These come from various sources, such as plants, marine organisms, microorganisms and cyanobacteria. The search for specific inhibitors is mainly performed in cell-based assays.


Protein kinases, activators, inhibitors, microorganisms, plants, marine organisms, cyanobacteria, cancer, cancer therapy, staurosporine, Rapamycin


Department of Chemistry, University of the Free State, Nelson Mandela Drive, Bloemfontein 9300, South Africa.

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