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Studies on the Biotransformations and Biodistributions of Metal-Containing Drugs Using X-Ray Absorption Spectroscopy

[ Vol. 11 , Issue. 5 ]

Author(s):

Jade B. Aitken, Aviva Levina and Peter A. Lay   Pages 553 - 571 ( 19 )

Abstract:


Most metal-based drugs are pro-drugs; therefore, it is essential that methods are developed to follow their speciation in biological fluids, cells and tissues. This will lead to both a better understanding of the factors that affect their efficacies and toxicities and, consequently, to the design of new and superior drugs. The use of X-ray absorption spectroscopy on bulk samples, and X-ray microprobe techniques on cells and tissues, provides unprecedented information on the biotransformations and biodistributions of metal-containing drugs that is required for a better understanding of their pharmacology. Here the methodologies that have been used on a range of metal- or metalloid-containing drugs and dietary supplements are reviewed, with an emphasis on research conducted within our group. In particular, applications of these techniques to anti-cancer, anti-diabetic, and anti-inflammatory drugs are discussed.

Keywords:

Metal-containing drugs, anti-cancer drugs, anti-diabetic drugs and supplements, anti-inflammatory drugs, X-ray absorption spectroscopy, biotransformations, biodistributions, efficacy, complexes, glutathione complex, multiple-scattering contributions, ARSENIC, SELENIUM, XAS and SRIXE techniques

Affiliation:

School of Chemistry, The University of Sydney, NSW, 2006, Australia.



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