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The p38α Kinase Plays a Central Role In Inflammation

[ Vol. 9 , Issue. 11 ]

Author(s):

Gary L. Schieven   Pages 1038 - 1048 ( 11 )

Abstract:


The p38 kinase plays a central role in inflammation, and it has been the subject of extensive efforts in both basic research and drug discovery. This review summarizes the biology of the p38 kinase with a focus on its role in inflammation. The p38 kinase regulates the production of key inflammatory mediators by cells of the innate immune system, including TNFα, IL-1β, and COX-2. In addition, p38 also acts downstream of cytokines such as TNFα, mediating some of their effects. Recently p38 has also been found to play a role in responses of T cells, including Th17 and regulatory T cells. Consistent with its important role in inflammation, recent evidence suggests cells may utilize a variety of feedback mechanisms to regulate and maintain p38 signal transduction. The biological processes regulated by p38 kinase suggest both a wide variety of potential indications for inhibitors and a level of complexity that has proven challenging to drug discovery efforts around this target.

, The, p38α, Kinase, Plays, a, Central, Role, In, Inflammation

Affiliation:

Bristol-Myers Squibb, P.O. Box 4000, Princeton, NJ 08543.



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