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Rho Kinase (ROCK) Inhibitors and Their Application to Inflammatory Disorders

[ Vol. 9 , Issue. 8 ]

Author(s):

Philip V. LoGrasso and Yangbo Feng   Pages 704 - 723 ( 20 )

Abstract:


Inhibitors of Rho kinase (ROCK) have many potential therapeutic applications. The biological focus of this overview will be on the role of ROCK in inflammatory disorders such as multiple sclerosis and asthma. Many ROCK inhibitors have been described in the primary and patent literature, and a diverse range of chemical scaffolds is beginning to emerge. Some of the structural classes that will be highlighted in this review include: isoquinolines, indazoles, aminofurazans, dihydropyrimidines, aminopyrimidines, benzodioxane carboxamides, benzimidazoles, and chroman amides.

Keywords:

Rho-kinase (ROCK), asthma, multiple sclerosis, isoquinoline, indazole, aminofurazans, benzimidazoles, aminopyrimidine, chroman amides

Affiliation:

Department of Molecular Therapeutics and Translational Research Institute, The Scripps Research Institute, 130 Scripps Way A2, Jupiter, FL, 33458, USA.



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