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Carbohydrate-Based Drugs in the Treatment of Epilepsy, Depression and Other Affective Disorders

[ Vol. 8 , Issue. 2 ]

Author(s):

Cecilia H. Marzabadi and Ian Jamie Talisman   Pages 159 - 170 ( 12 )

Abstract:


Mental illness affects a quarter of the US population. Recently, it has been shown that new, carbohydrate-based drugs hold promise in the treatment of central nervous system (CNS) disorders. A variety of ways in which drugs of this sort may reduce the symptoms of epilepsy, depression and other affective disorders have been proposed, including: targeting the immune system, disrupting glycolysis, acting at different sites in the hypothalamic-pituitary-adrenal (HPA) axis, and targeting specific biochemical pathways such as the inositol pathway. In the present review, the structureactivity relationships (SARs) of a wide variety of CNS-active carbohydrates are presented.

Keywords:

Glycolysis, topiramate, saponins, steroidal glycosides, capsular saccharides

Affiliation:

Seton Hall University,Department of Chemistry and Biochemistry, 400 South Orange Ave., South Orange, NJ 07079, USA.



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