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Pyranose N-Glycosyl Amines: Emerging Targets With Diverse Biological Potential

[ Vol. 8 , Issue. 2 ]

Author(s):

Peter Norris   Pages 101 - 113 ( 13 )

Abstract:


Interest in the chemistry and biological properties of non-nucleoside N-glycosidic compounds has gathered pace over the past several years; the occurrence of the N-glycoside moiety in glycoproteins and a range of active natural products has prompted the synthesis of a diverse spectrum of related materials with promising potential in medicinal chemistry. Particularly prominent has been the synthesis of novel N-glycosyl amides, 1,2,3-triazoles, and progress in the construction and diversification of natural products such as the mannopeptimycins and indolocarbazoles, each of which are discussed in this article.

Keywords:

N-Glycosyl amine, N-glycosyl amide, N-glycosylated heterocycles

Affiliation:

Department of Chemistry,Youngstown State University, 1 University Plaza, Youngstown, OH 44555,USA.



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