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Application of High-Throughput, Molecular-Targeted Screening to Anticancer Drug Discovery

[ Vol. 2 , Issue. 3 ]

Author(s):

Robert H. Shoemaker, Dominic A. Scudiero, Giovanni Melillo, Michael J. Currens, Anne P. Monks, Alfred A. Rabow, David G. Covell and Edward A. Sausville   Pages 229 - 246 ( 18 )

Abstract:


Increasing insight into the genetics and molecular biology of cancer has resulted in the identification of an increasing number of potential molecular targets for anti-cancer drug discovery and development. These targets can be approached through exploitation of emerging structural biology,”rational“ drug design, screening of chemical libraries, or a combination of these methods. In this article we discuss the application of high-throughput screening to anti-cancer drug discovery, with special reference to approaches used at the U.S. National Cancer Institute.

Keywords:

anticancer drug discovery, molecular medicine, (cat) assays

Affiliation:

Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick, Building 440, Frederick, Maryland, 21702-1201, USA



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