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Automation of Biomolecular NMR Screening

[ Vol. 3 , Issue. 1 ]

Author(s):

Alfred Ross and Hans Senn   Pages 55 - 67 ( 13 )

Abstract:


For NMR based screening we review equipment needed for automated preparation of samples and acquisition of a large number of data sets. Hardware connecting lab-bench and NMR spectrometer is described. We focus on software used for automated calculation of the similarity between spectra - a prerequisite for the identification of test compounds interacting with a target-molecule.

Keywords:

ligand, protein, screening, automation, pca

Affiliation:

Hoffmann LaRoche AG, Department for Biostructural Research (PRBT), Grenzacher Str., CH- 4070 Basel, Switzerland



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