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Imino-Sugar-Based Nucleosides

[ Vol. 3 , Issue. 5 ]

Author(s):

Vern L. Schramm and Peter C. Tyler   Pages 525 - 540 ( 16 )

Abstract:


Continued interest in imino-sugar nucleosides derives from the observations that N-ribosyltransferases are powerfully inhibited by imino-C-nucleoside analogues that mimic the ribooxacarbenium ion nature of their transition states. The synthesis of such compounds is challenging, and synthetic routes to imino- and imino-Cnucleosides are reviewed, together with the nature of the N-ribosyltransferases that are targets for these analogues. Examples are given to exemplify the promise these compounds hold for the treatments of biological disorders.

Keywords:

imino-sugar-based, iminonucleosides, imino-c-nucleosides

Affiliation:

Carbohydrate Chemistry, Industrial Research Limited, P O Box 31310, Lower Hutt, New Zealand



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