Submit Manuscript  

Article Details


Iminosugars and Relatives as Antiviral and Potential Anti-infective Agents

[ Vol. 3 , Issue. 5 ]

Author(s):

P. Greimel, J. Spreitz, A. E. Stutz and T. M. Wrodnigg   Pages 513 - 523 ( 11 )

Abstract:


Iminosugars have emerged in the literature during mid-1960s as synthetic compounds. Around the same time, the first examples were found in Nature and their interesting enzyme inhibitory properties were recognised. Due to their powerful interference with glycohydrolases (glycosidases) as well as glycosyltransferases, quite a few representatives exhibit notable biological activities. These range from antidiabetic, insect antifeedant, nematicidal, plant growth regulating to immunomodulating, anti-cancer as well as - in selected cases - anti-infective properties. The latter will be the focus of the following survey.

Keywords:

iminosugar, iminoalditol, antiinfective, antiviral, antibacterial, antifungal, antiprotozoan

Affiliation:

Glycogroup, Institut fur Organische Chemie der Technischen Universitat Graz, Stremayrgasse 16, A-8010 Graz, Austria



Read Full-Text article