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The Impact of Combinatorial Methodologies on Medicinal Chemistry

[ Vol. 4 , Issue. 7 ]

Author(s):

Rosario M. Sanchez-Martin, Stifun Mittoo and Mark Bradley   Pages 653 - 669 ( 17 )

Abstract:


Combinatorial chemistry has had a major impact on the discovery and optimisation of potential lead compounds. This review details some of the fundamental principles behind combinatorial chemistry and describes a variety of methods employed in the search for new therapeutically interesting compounds including the concept of dynamic combinatorial chemistry as a method of selecting active compounds from a mixture. It also outlines methods used to analyse resin bound products and describes how solution phase library generation may be aided by the use of resin bound reagents and scavengers.

Keywords:

Methodologies, scavengers, combinatorial chemistry

Affiliation:

Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK



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