Rosario M. Sanchez-Martin, Stifun Mittoo and Mark Bradley Pages 653 - 669 ( 17 )
Combinatorial chemistry has had a major impact on the discovery and optimisation of potential lead compounds. This review details some of the fundamental principles behind combinatorial chemistry and describes a variety of methods employed in the search for new therapeutically interesting compounds including the concept of dynamic combinatorial chemistry as a method of selecting active compounds from a mixture. It also outlines methods used to analyse resin bound products and describes how solution phase library generation may be aided by the use of resin bound reagents and scavengers.
Methodologies, scavengers, combinatorial chemistry
Combinatorial Centre of Excellence, Department of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK