Thomas S. Rush III and Robert Powers Pages 1311 - 1327 ( 17 )
The following review discusses the successful application of X-ray, NMR, and molecular modeling in the design of potent and selective inhibitors of matrix metalloproteinases (MMPs) and TNFα-converting enzyme (TACE) from Wyeth. The importance of protein and ligand mobility as it impacts structure-based design is also discussed. The MMPs are an active target for a variety of diseases, including cancer and arthritis.
structure-based drug design, matrix metalloproteinase, matrix metalloprotease, x-ray, nmr, molecular modeling, inhibitor, mmp
Structural Biology&Computational Chemistry, Department of Chemical&Screening Sciences,Wyeth Research, 87 Cambridge Park Dr. Cambridge, MA, 02140, USA