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Recent Advances in Antiviral Nucleoside and Nucleotide Therapeutics

[ Vol. 5 , Issue. 13 ]

Author(s):

Claire Simons, Qinpei Wu and Thet T. Htar   Pages 1191 - 1203 ( 13 )

Abstract:


Recent developments in nucleoside/nucleotide therapeutics and antiviral drug targets are described covering progress in the development of nucleoside/nucleotide mimetics for the treatment of influenza virus, human immunodeficiency virus type 1, hepatitis B and C virus, herpes virus infections; including herpes simplex virus, cytomegalovirus and varicella zoster virus infections, and the highly pathogenic poxviruses (variola, vaccinia and mokey pox) and filoviruses (Ebola and Marburg).

Keywords:

nucleoside/nucleotide therapeutics, influenza virus, human immunodeficiency virus, hepatitis b and c virus, herpes virus, poxvirus, filovirus, sirna, antisense oligonucleotides

Affiliation:

Medicinal Chemistry Division, Welsh School of Pharmacy, Cardiff University, King Edward VIIAvenue, Cardiff CF10 3XF, UK.



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