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New Approaches for the Treatment of Pain: The GDNF Family of Neurotrophic Growth Factors

[ Vol. 5 , Issue. 6 ]

Author(s):

Dinah W. Y. Sah, Michael H. Ossipov, Anthony Rossomando, Laura Silvian and Frank Porreca   Pages 577 - 583 ( 7 )

Abstract:


This article focuses on the GDNF family of neurotrophic factors as a potential new class of therapeutics for neuropathic pain, with a particular emphasis on the ligands, artemin and GDNF. In vivo activity of the ligands, expression of ligands and receptors after peripheral nerve injury, and modulation of nerve injury-induced changes by the ligands are reviewed in detail. Structural considerations, particularly with regard to implications for binding interactions and biological activity are discussed.

, New, Approaches, for, the, Treatment, of, Pain:, The, GDNF, Family, of, Neurotrophic, Growth, Factors

Affiliation:

Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724.



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