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Photosensitive Precursors to Nitric Oxide

[ Vol. 5 , Issue. 7 ]

Author(s):

Christopher M. Pavlos, Hua Xu and John P. Toscano   Pages 637 - 647 ( 11 )

Abstract:


The photochemistry and use of recently developed photosensitive precursors to nitric oxide (NO) are reviewed. As "caged NO" donors these precursors are able to deliver NO in a spatially and temporally controllable manner. These properties have made such precursors useful in applications in biology and medicine, especially in elucidating neurophysiological roles of NO and in new cancer therapies.

Keywords:

photodynamic therapy, diazeniumdiolate, nucleophiles, photolysis, meta substituents, photorelease

Affiliation:

Department of Chemistry, JohnsHopkins University, 3400 North Charles Street, Baltimore, Maryland 21218,USA;



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