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AMPA Receptor Antagonists as Potential Anticonvulsant Drugs

[ Vol. 5 , Issue. 1 ]

Author(s):

Giovambattista De Sarro, Rosaria Gitto, Emilio Russo, Guido Ferreri Ibbadu, Maria Letizia Barreca, Laura De Luca and Alba Chimirri   Pages 31 - 42 ( 12 )

Abstract:


Over the last years α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors (AMPARs) have been intensively studied owing to their crucial role in physiological and pathological processes. Efforts targeting AMPAR have been focused on identification of ligands as potential therapeutic agents useful in the prevention and treatment of a variety of neurological and non-neurological diseases. In particular, extensive work was addressed to the discovery of selective antagonists some of which proved to be potent anticonvulsant agents.

Keywords:

glutamate, ampa receptor antagonists, ampar, anticonvulsants

Affiliation:

Dipartimento Farmaco-Chimico, Facolta di Farmacia, Universita di Messina, Viale Annunziata I-98168Messina, Italy.



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