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Recent Advances in the Synthesis of C-oligosaccharides

[ Vol. 5 , Issue. 14 ]

Author(s):

Xuejun Yuan and Robert J. Linhardt   Pages 1393 - 1430 ( 38 )

Abstract:


This paper reviews the recent advances in the synthesis of catabolically stable sugar mimetics, Coligosaccharides. These compounds are synthetic analogs of the naturally occurring O-oligosaccharides, in which the interglycosidic oxygen has been replaced by a methylene group. This review is organized in terms of chemistry used to assemble C-oligosaccarides under the sub-headings: anionic approaches, cationic methods, reductive glycosyl samarium chemistry, cyclization methodology, and free radical chemistry.

Keywords:

Cross-aldol reaction, Nitro Stabilized Anions, halogenation-RBR, samariumn species, Ganglioside, exo-glycal

Affiliation:

Department of Chemistry andChemical Biology, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.



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