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Recent Advances in the Synthesis of C-linked Glycoconjugates

[ Vol. 5 , Issue. 14 ]

Author(s):

Elisabeth v. Moos and Robert N. Ben   Pages 1351 - 1361 ( 11 )

Abstract:


During the last five years, the scientific community has seen a dramatic increase in the number of synthetic methods or strategies to prepare C-linked glycoconjugates. One reason for this increase is that the biological significance and roles of many O- and N-linked glyconconjugates has become evident. This review will summarize the biological importance of glycoconjugates and outline recent advances in the preparation of C-linked glycoconjugates that have appeared in the literature since the new millennium.

Keywords:

Asparagine, double-bond isomerization, Ramberg-Backlund rearrangement, Tebbe/Claisen approach, C-Mannosyltryptophan

Affiliation:

Department of Chemistry,University of Ottawa, Ottawa, ON, Canada, K1N 6N5.



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