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Cholesteryl Ester Transfer Protein: Pharmacological Inhibition for the Modulation of Plasma Cholesterol Levels and Promising Target for the Prevention of Atherosclerosis.

[ Vol. 5 , Issue. 3 ]

Author(s):

Roger B. Ruggeri   Pages 257 - 264 ( 8 )

Abstract:


Cholesteryl ester transfer protein (CETP) facilitates the exchange of neutral lipids (such as cholesteryl esters and triglycerides) between anti-atherogenic HDL particles and pro-atherogenic VLDL and LDL particles in human plasma. Individuals possessing a genetic deficiency for CETP have higher HDL cholesterol and lower LDL cholesterol and may have a reduced risk for developing cardiovascular disease. Small molecule inhibitors of CETP are being developed that would appear to provide a beneficial change in lipoprotein profile. However, randomized clinical trials are ultimately required to determine whether CETP inhibition will afford a reduction in cardiovascular events.

Keywords:

low-density lipoprotein cholesterol (ldl-c), coronary heart disease (chd), reverse cholesterol transport(rct), inflammatory processes, vascular endothelial cells, glycopeptide, phospholipids

Affiliation:

Department of Medicinal Chemistry, Cardiovascular and Metabolic Diseases, Pfizer Global Researchand Development, Groton, CT 06340, USA.



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