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Selective Agents for Serotonin2C (5-HT2C) Receptor

[ Vol. 6 , Issue. 18 ]


Enza Lacivita and Marcello Leopoldo   Pages 1927 - 1970 ( 44 )


The serotonin2C (5-HT2C) receptor has attracted a lot of attention owing to its role in appetite regulation, depression, obsessive-compulsive disorder (OCD), panic disorders, and substance abuse. This review summarizes nonpatent and patent literature up to November 2005 that deals with the synthesis and characterization of selective 5-HT2C receptor agonists and antagonists. Highlights on structure-activity relationships have been included, when possible.


CYP1A2, mCPP, RO600175, anxiolytic, WAY-629, phenylpiperazine


Universita degli Studi di Bari, Dipartimento Farmaco-Chimico, via Orabona, 4, 70125, Bari, Italy.

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