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Genetically Modified Mice Models for Alzheimers Disease

[ Vol. 6 , Issue. 6 ]

Author(s):

Sethu Sankaranarayanan   Pages 609 - 627 ( 19 )

Abstract:


Transgenic mice models for Alzheimers disease (AD) are essential to the understanding of disease pathophysiology, develop robust behavioral models and predict outcomes from pharmacological interventions. In the last 10 years, numerous mice models have been developed particularly focusing on the amyloid precursor protein-processing pathway and Tau pathology since brain amyloid deposits and Tau tangles are some of the primary neuropathological consequences of AD. Current views on the amyloid hypothesis and mice models relating to the role of soluble Aβ oligomers and intracellular Aβ in AD pathophysiology will be reviewed. Several novel transgenic mice models that have recently been developed and their potential impact on understanding disease pathogenesis will also be summarized.

Keywords:

Alzheimer's, transgenic, APP, Tau, Abeta, amyloid, oligomer, intraneuronal, neurodegeneration, mutation

Affiliation:

Merck Research Labs, WP44E-200, 770 Sumneytown Pike, West Point, Pa 19486, USA.



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