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1,3,4-Oxadiazoles as Potential Pharmacophore for Cytotoxic Potentiality: A Comprehensive Review

[ Vol. 21 , Issue. 15 ]

Author(s):

Divya Sharma, Salahuddin*, Vikas Sharma, Rajnish Kumar, Sagar Joshi, Sunita Kumari, Shivani Saxena, Avijit Mazumder, Mohammad Shahar Yar and Mohamed Jawed Ahsan   Pages 1377 - 1397 ( 21 )

Abstract:


Cancer is a kind of human cell degenerative disease that has affected many people for sev-eral years. Cancer is caused due to the abnormal growth of cells in every particular part of the body. The 1,3,4-oxadiazole ring is found to be a binding moiety that has anticancer potential. Various works on the 1,3,4-oxadiazole moiety showing anticancer activity have been reported. The present analysis summarizes general synthetic methods for 1,3,4 oxadiazole. Different receptors on which these drug acts are discussed. This review also presents pharmacophore models for topoisomerase-I, histone deacetylase, and epidermal growth factor enzymes.

Keywords:

Cancer, 1, 3, 4-oxadiazole, Anticancer potential, Synthetic methods, Receptors, Pharmacophore

Affiliation:

Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Plot No. 19, KP-2, Greater Noida, Uttar Pradesh-201306, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard University, Hamdard Nagar, New Delhi-110062, Department of Pharmaceutical Chemistry, Maharishi Arvind College of Pharmacy, Ambabari Circle, Jaipur, Raja-sthan- 302039



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