Submit Manuscript  

Article Details


Discovery and Development of Inflammatory Inhibitors from 2-Phenylchromonone (Flavone) Scaffolds

[ Vol. 20 , Issue. 28 ]

Author(s):

Chen Xu, Meng-Yuan Fang, Ke Wang, Jing Liu, Guang-Ping Tai, Zhao-Ting Zhang* and Ban-Feng Ruan*   Pages 2578 - 2598 ( 21 )

Abstract:


Flavonoids are compounds based on a 2-phenylchromonone scaffold. Flavonoids can be divided into flavonoids, flavonols, dihydroflavones, anthocyanins, chalcones and diflavones according to the oxidation degree of the central tricarbonyl chain, the connection position of B-ring (2-or 3-position), and whether the tricarbonyl chain forms a ring or not. There are a variety of biological activities about flavonoids, such as anti-inflammatory activity, anti-oxidation and anti-tumor activity, and the antiinflammatory activity is apparent. This paper reviews the anti-inflammatory activities and mechanisms of flavonoids and their derivatives reported in China and abroad from 2011 till date (2011-2020), in order to find a good drug scaffold for the study of anti-inflammatory activities.

Keywords:

Natural products, Flavonoids, Anti-inflammatory activity, Anti-inflammatory mechanism, 2-phenylchromonone scaffold, Drug.

Affiliation:

School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, Center of Tobacco Industry Development, Xuanzhou District, Xuancheng, 242000, Key Lab of Biofabrication of Anhui Higher Education, Hefei University, Hefei 230601, Key Lab of Biofabrication of Anhui Higher Education, Hefei University, Hefei 230601, Center of Tobacco Industry Development, Xuanzhou District, Xuancheng, 242000, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009

Graphical Abstract:



Read Full-Text article