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Multifunctional Nanoparticles in Precise Cancer Treatment: Considerations in Design and Functionalization of Nanocarriers

[ Vol. 20 , Issue. 27 ]

Author(s):

Lina Lu, Shuhe Kang, Chao Sun, Chufeng Sun, Zhong Guo, Jia Li, Taofeng Zhang, Xingping Luo and Bin Liu *   Pages 2427 - 2441 ( 15 )

Abstract:


Nanotechnology has revolutionized cancer treatment in both diagnosis and therapy. Since the initial application of nanoparticles (NPs) in cancer treatment, the main objective of nanotechnology was developing effective nanosystems with high selectivity and specificity for cancer treatment and diagnosis. To achieve this, different encapsulation and conjugation strategies along with surface functionalization techniques have been developed to synthesize anticancer drugs loaded NPs with effective targeting to specific tumor cells. The unique physicochemical attributes of NPs make them promising candidates for targeted drug delivery, localized therapies, sensing, and targeting at cellular levels. However, a nanosystem for localized and targeted cancer managements should overcome several biological barriers and biomedical challenges such as endothelial barriers, blood brain barrier, reticuloendothelial system, selective targeting, biocompatibility, acute/chronic toxicity, tumor-targeting efficacy. The NPs for in vivo applications encounter barriers at system, organ, and the cellular level. To overcome these barriers, different strategies during the synthesis and functionalization of NPs should be adapted. Pharmacokinetics and cellular uptake of NPs are largely associated with physicochemical attributes of NPs, morphology, hydrodynamic size, charge, and other surface properties. These properties can be adjusted during different phases of synthesis and functionalization of the NPs. This study reviews the advances in targeted cancer treatment and the parameters influencing the efficacies of NPs as therapeutics. Different strategies for overcoming the biological barriers at cellular, organ and system levels and biomedical chal

Keywords:

Nanoparticles, Targeted cancer treatment, Physiochemical characteristics, Targeting strategies, Clinical applications, Toxicity.

Affiliation:

School of Chemical Engineering, Northwest Minzu University, Lanzhou, Gansu, School of Chemical Engineering, Northwest Minzu University, Lanzhou, Gansu, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, School of Chemical Engineering, Northwest Minzu University, Lanzhou, Gansu, Medical College of Northwest Minzu University, Lanzhou 730000, Gansu, School of Chemical Engineering, Northwest Minzu University, Lanzhou, Gansu, School of Nuclear Science and Technology, Lanzhou University, Lanzhou, Gansu, School of Chemical Engineering, Northwest Minzu University, Lanzhou, Gansu, School of Nuclear Science and Technology, Lanzhou University, Lanzhou, Gansu



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